Predictive formulation science

Where molecular
precision meets
wellness.

Luminae Research produces hormone-binding intelligence reports for premium supplement and wellness brands — grounded in computational molecular modeling borrowed from pharmaceutical drug discovery.

Request a sample report See the method
i
Research intelligence for product and R&D decisions. Not medical advice. Clients retain full responsibility for formulation and compliance.
Receptor panel — 7 female hormone targets
ERα
Estrogen Receptor Alpha
ERβ
Estrogen Receptor Beta
PR
Progesterone Receptor
AR
Androgen Receptor
GR
Glucocorticoid Receptor
TRα / TRβ
Thyroid Receptors
~2.8s
per binding prediction (Vina screening)
0.92
Boltz-2 confidence score, jujube vs ERα
The method

Pharma-grade
modeling, applied
to botanicals.

We adapt computational techniques from pharmaceutical drug discovery to screen food and botanical compounds — through a female hormone receptor lens.

1
Ingredient bioactive retrieval
We pull known bioactive compounds from PubChem for your target ingredient panel (e.g. jujube, soy, adaptogens).
2
Rapid docking screen
AutoDock Vina runs binding affinity predictions across all 7 receptors — delivering hundreds of data points in minutes.
3
Deep validation of top hits
High-scoring compounds are validated with Boltz-2 structure prediction, yielding confidence scores alongside binding energies.
4
Formulation intelligence report
Results are translated into a clean, decision-ready report your R&D or brand team can act on directly.
Sample data — jujube compounds × ERβ
Boltz-2 validation results · binding energy (kcal/mol)
Compound Receptor ΔG Signal
Quercetin ERβ −8.4 Strong
Rutin ERβ −7.9 Strong
Betulinic acid ERβ −7.2 Moderate
Oleanolic acid ERβ −6.8 Moderate
Spinosin ERβ −6.1 Moderate
Control validation — quercetin vs COX-2
CompoundTargetΔG observedExpected
QuercetinCOX-2−9.6−7 to −9
GenisteinERα−6.9−8 to −10
GlucoseCOX-2−6.2−3 to −5
What you receive

Research-grade outputs,
brand-ready format.

Every report is structured to move directly into R&D workflows — no reformatting, no interpretation gap.

Hormone receptor profile

Ranked binding affinities across all 7 female-relevant receptors — ERα, ERβ, PR, AR, GR, TRα, TRβ — with kcal/mol scores and Boltz-2 confidence ratings for top hits.

ΔG scores Boltz-2 confidence 7 receptors

Ingredient compound map

A full compound-level mapping from your ingredient's bioactive panel to the receptor it most plausibly engages — the molecular rationale behind your formula's claims.

PubChem sourced Target mapping Citation trail

Formulation shortlist

Prioritized ingredient recommendations with trade-off analysis — coverage breadth vs. constraint fit — designed to be forwarded to your CMO or R&D team without rework.

Trade-off analysis CMO-ready Brand constraints
Who we serve

Built for brands who want
the real science behind the story.

We work with product, R&D, and brand teams at premium wellness companies who need more than a literature review.

Supplement brands

You're launching a hormone-health SKU and need defensible, mechanism-level rationale for every ingredient — not just trademarked blends and vague citations.

Functional food & beverage

You want to move beyond "adaptogen" positioning and build claims grounded in receptor-level binding data your science team can stand behind.

R&D and innovation teams

You're evaluating botanical ingredients at speed and need a fast, structured screen before committing to clinical investment or CMO formulation trials.

Work with us

Request a
sample report.

Tell us your ingredient focus and we'll send a sample showing exactly the depth and format of what you'd receive.